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    CJC-1295 + Ipamorelin

    Growth Hormone

    CJC-1295 (No DAC) 5mg + Ipamorelin 5mg — Pre-Blended GH Secretagogue Stack

    PepPal is a research assistant. All information is provided for educational and research purposes only and is not medical advice. Peptides discussed are not approved for human consumption unless prescribed by a licensed medical professional.

    Overview

    CJC-1295 (No DAC) and Ipamorelin are a pre-blended GH secretagogue stack that work on two different receptors in the GH axis — GHRH and ghrelin receptors — producing synergistic pulsatile GH release larger than either peptide alone. The no-DAC version preserves the body's natural pulsatile GH rhythm.

    Mechanism of Action

    CJC-1295 (No DAC / Mod GRF 1-29) is a GHRH analogue stimulating pituitary GH production. Ipamorelin is a selective ghrelin receptor agonist triggering clean GH pulses without significantly raising cortisol or prolactin. Together they produce synergistic pulsatile GH release.

    Research Contexts

    Growth hormone elevation • Body composition • Sleep quality • Anti-aging research • Recovery • Cognitive clarity

    Dosing (PepPal Protocol)

    PepPal only publishes dosing from our vetted protocol PDFs. For peptides without an official PepPal protocol, see the Protocols page.

    Step 1: 12 units/day (200 mcg of each). Step 2: 18 units/day (300 mcg of each). Once daily subcutaneous, evening/pre-sleep, fasted. 12–16 weeks on / 2–4 weeks off.

    Reconstitution Guide

    Vial size: 10 mg (5 mg CJC-1295 + 5 mg Ipamorelin) Water volume: 3 mL bacteriostatic water Concentration: 0.1667 mg per unit per peptide Add 3 mL of bacteriostatic water slowly along the vial wall — do not shake. 12 units = 200 mcg of each, 18 units = 300 mcg of each. Inject at least 1 hour before eating or 1.5 hours after last meal. Pre-sleep on empty stomach is optimal (insulin blunts GH release).

    Storage Guidelines

    Before reconstitution: Store at -20°C. Protect from light and moisture. After reconstitution: Refrigerate at 2–8°C. Use within 3–4 weeks.

    Half-Life & Stability

    Half-life: CJC-1295 (No DAC): ~30 minutes. Ipamorelin: ~2 hours. Each injection produces a discrete GH pulse that clears within 30–60 minutes. Stability: Use promptly after reconstitution. Can be run indefinitely though 12–16 weeks on / 2–4 weeks off is recommended best practice.