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    GHK-Cu

    Anti-Aging

    Copper Peptide GHK-Cu

    PepPal is a research assistant. All information is provided for educational and research purposes only and is not medical advice. Peptides discussed are not approved for human consumption unless prescribed by a licensed medical professional.

    Overview

    GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. It is extensively researched for skin remodeling, wound healing, and anti-aging effects. Effects are cumulative and subtle — patience is key.

    Mechanism of Action

    GHK-Cu stimulates collagen and glycosaminoglycan synthesis, promotes stem cell activity, has anti-inflammatory and antioxidant effects, and modulates gene expression related to tissue remodeling.

    Research Contexts

    Skin rejuvenation • Wound healing • Hair growth • Anti-aging • Collagen synthesis

    Dosing (PepPal Protocol)

    PepPal only publishes dosing from our vetted protocol PDFs. For peptides without an official PepPal protocol, see the Protocols page.

    Step 1: 1–2 mg daily subcutaneously. Step 2: 2.5–3 mg daily (advance when Step 1 is comfortable). No cycling off required — GHK-Cu can be used continuously.

    Reconstitution Guide

    Vial size: 50 mg Water volume: 3 mL bacteriostatic water Concentration: 0.167 mg per unit Add 3 mL of bacteriostatic water slowly along the vial wall — do not shake. 1 mg = 6 units, 2 mg = 12 units, 3 mg = 18 units. Rotate injection sites daily (abdomen, outer thigh, or deltoid).

    Storage Guidelines

    Before reconstitution: Store powder at -20°C, protected from light and moisture. After reconstitution: Refrigerate at 2–8°C. Use within 4 weeks.

    Half-Life & Stability

    Half-life: Not well characterized for peptide form; copper complex is relatively stable Stability: Stable when properly stored. Mild injection site redness/swelling is normal and expected — not a reason to hold dose.