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    Selank

    Cognitive

    Selank (Synthetic Tuftsin Analogue)

    PepPal is a research assistant. All information is provided for educational and research purposes only and is not medical advice. Peptides discussed are not approved for human consumption unless prescribed by a licensed medical professional.

    Overview

    Selank is a synthetic heptapeptide analogue of Tuftsin, developed in Russia alongside Semax. It is a registered pharmaceutical for anxiety disorders, asthenic conditions, and cognitive dysfunction. Selank produces a calming anxiolytic effect without sedation, amnesia, or dependence risk — the anxiolytic counterpart to Semax's stimulating profile.

    Mechanism of Action

    Selank works primarily through GABA-A receptor modulation and enkephalin stabilisation, producing anxiolytic effects without sedation or dependence. It also upregulates BDNF and serotonin expression, contributing to mood stability, stress resilience, and cognitive clarity.

    Research Contexts

    Anxiety reduction • Cognitive enhancement • Stress resilience • GABA modulation • Mood stabilisation • Immune modulation

    Dosing (PepPal Protocol)

    PepPal only publishes dosing from our vetted protocol PDFs. For peptides without an official PepPal protocol, see the Protocols page.

    250–500 mcg subcutaneous or intranasal daily. 12 weeks on / 4 weeks off. Short cycles (14 days on / 7–14 days off) also valid. Many users find 250 mcg to be their optimal dose. Also suitable for as-needed use during acute stress.

    Reconstitution Guide

    Vial size: 10 mg Water volume: 1 mL bacteriostatic water Concentration: 0.1 mg per unit (10 mg/mL) Add 1 mL of bacteriostatic water slowly along the vial wall — do not shake. 250 mcg = 2.5 units, 500 mcg = 5 units. Also available as a ready-to-use nasal spray (100 mcg per actuation — split daily dose across 2–3 sessions).

    Storage Guidelines

    Before reconstitution: Store at -20°C or refrigerated. Protect from light. After reconstitution: Refrigerate at 2–8°C. Use within 3–4 weeks.

    Half-Life & Stability

    Half-life: Rapidly metabolized (minutes), but anxiolytic and cognitive effects persist 1–4 hours via downstream signaling Stability: Stable when refrigerated. Timing is flexible — calming rather than stimulating, so no sleep disruption risk. No dependence or withdrawal.